Pharmacokinetic-Pharmacodynamic Modelling of Opioids in Healthy Human Volunteers. A MiniReview
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic-pharmacodynamic modelling of opioids in healthy human volunteers. a minireview.
Pain is characterized by its multi-dimensional nature, explaining in part why the pharmacokinetic/pharmacodynamic (PK/PD) relationships are not straightforward for analgesics. The first part of this MiniReview gives an overview of PK, PD and PK/PD models, as well as of population approach used in analgesic studies. The second part updates the state-of-the-art in the PK/PD relationship of opioid...
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ژورنال
عنوان ژورنال: Basic & Clinical Pharmacology & Toxicology
سال: 2011
ISSN: 1742-7835
DOI: 10.1111/j.1742-7843.2011.00814.x